Clomid - Optimum laboratories


Clomid is a SERM that is specifically used as a fertility aid due to its ability to enhance the release of gonadotropins. It has the ability to oppose the negative feedback of estrogens on the Hypothalamic Pituitary Ovarian Axis. This will increase the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) significantly. By increasing gonadotropin release, this can lead to the egg being released, thereby increasing the chance of conception.

Athletes take Clomid to enhance their physical performance in sports. It is capable of interacting with the estrogen receptor containing tissues including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix.

Clomid (Clomiphene Citrate) may compete with estrogen for estrogen receptor binding sites and may delay replenishment of intracellular estrogen receptors. It initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular rupture. The first endocrine event in response to a course of clomiphene therapy is an increase in the release of pituitary gonadotropins. This initiates steroidogenesis and folliculogenesis, resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. Following ovulation, plasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle.

It is used during the PCT period. The use of anabolic steroids will suppress natural testosterone production. Testosterone production occurs in the testicles of men, this much most understand but production does not begin there. In order for production to occur the pituitary must release adequate hormones such as LH which in-turn signal to the testicles to produce testosterone. Fortunately, Clomid acts to stimulate such gonadotropins thereby stimulating natural testosterone production.


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